Determination of Red Blood Cells Trace Elements as Risk Factors for Breast Cancer by X-Ray Fluorescence

Alkhansa Salih Mahmoud

Radiobiology Department, Sudan Atomic Energy Commission, Khartoum, Sudan.

Khalda Awad Albadwa

Applied Nuclear Science Laboratories, Sudan Atomic Energy Commission, Khartoum, Sudan.

Khalid Hussein Bakheit *

Clinical Biochemistry Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

*Author to whom correspondence should be addressed.


Abstract

Introduction: Breast cancer is a heterogeneous disease that cause women death. Several factors influence the development of breast cancer. Trace elements are associated with breast cancer risk factors. This study investigated six trace elements in red blood cells of women newly diagnosed with breast cancer, compared to healthy women.

Methods: 38 Sudanese women participated in this study; 19 of them were breast cancer patients, who were compared with 19 healthy women of the same age to determine the concentrations of K, Zn, Cu, Fe, Ca, and Pb in red blood cells by X-ray fluorescence.

Results: K concentration was significantly increased in breast cancer patients compared to the control group (P= < 0.001). Zn and Cu were slightly decreased in patients compared to the control group. In contrast, insignificant increase was observed for Fe, Ca and Pb in breast cancer patients compared to the control group. Correlations between Fe and Cu, K and Pb were found in breast cancer patients.

Conclusion: High K concentration in red blood cells is associated with breast cancer risk in Sudanese women. K can be used as a biomarker for breast cancer prognosis and development.

Keywords: Red blood cells, trace elements, risk factors, breast cancer


How to Cite

Mahmoud, A. S., Albadwa, K. A., & Bakheit, K. H. (2022). Determination of Red Blood Cells Trace Elements as Risk Factors for Breast Cancer by X-Ray Fluorescence. International Journal of Biochemistry Research & Review, 31(10), 74–80. https://doi.org/10.9734/ijbcrr/2022/v31i10789

Downloads

Download data is not yet available.

References

Rezaei M, Hashemi M, Hashemi SM, Mashhadi MA, Taheri M. APOBEC3 deletion is associated with breast cancer risk in a sample of southeast Iranian population. Int J Mol Cell Med. 2015; 4(2):103-8.

Hashemi M, Yousefi J, Hashemi SM, Amininia S, Ebrahimi M, Taheri M, et al. Association between programmed cell death 6 interacting protein insertion/ deletion polymorphism and the risk of breast cancer in a sample of Iranian population. Dis Markers. 2015: 854621.

Key TJ, Verkasalo PK, Banks E. Epidemiology of breast cancer. Lancet Oncol. 2001;2(3):133-40.

Hashemi SM, Arbabi N, Hashemi M, Mashhadi MA, Allahyari A, Sadeghi M. Association between VDR gene polymorphisms (rs 1544410, rs 7975232, rs 2228570, rs 731236 and rs 11568820), and susceptibility to breast cancer in a sample of Southeastern Iranian population. Int J Cancer Manag. 2017;10(3).

John E, Laskow TC, Buchser WJ, Pitt BR, Basse PH, Butterfield LH, et al. Zinc in innate and adaptive tumor immunity. J Transl Med. 2010;8:118

Suzana S, Cham BG, Ahmad Rohi G, Mohd Rizal R, Fairulnizal MN, Normah H, et al. Relationship between selenium and breast cancer: A case-control study in the Klang valley. Singapore Med J. 2009;50:265-9.

Ding X, Jiang M, Jing H, Sheng W, Wang X, Han J, et al. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China. Environ Sci Pollut Res Int. 2015;22(10):7930-5.

Shamberger RJ. Calcium, magnesium, and other elements in the red blood cells and hair of normals and patients with premenstrual syndrome. Biol Trace Elem Res. 2003;94(2):123-9.

Susan J. Fairweather-Taita Kevin Cashman. Menirals and trace elements. Nutrition for the primary care provider. World Rev Nutr Diet. 2015;111:45–52.

Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M et al. Understanding copper homeostasis in humans and copper effects on health. Biol Res. 2006;39:183-187.

Classen HG, Gröber U, Löw D, Schmidt J, Stracke H. Zinc deficiency: Symptoms, causes, diagnosis and therapy. Med Monatsschr Pharm. 2011;34:87-95.

Silva MP, Tomal A, Perez CA, Ribeiro-Silva A, Poletti ME. Determination of Ca, Fe, Cu and Zn and their correlations in breast cancer and normal adjacent tissues. X-Ray Spectrom. 2009;38(2):103-111.

Poletti ME, Goncalves OD, Perez CA, Magalhaes SD. A preliminary study of the distribution of trace elements in healthy and neoplastic breast tissues with synchrotron radiation X-ray fluorescence. Radiat Phys Chem. 2004;71(3–4):975–976.

Janssens K: X-ray based methods of analysis. Non-Destructive Micro Analysis of Cultural Heritage Materials. 2004;42:129-226.

Cinosi A, Andriollo N, Pepponi G, Monticelli D. A novel total reflection X-ray fluorescence procedure for the direct determination of trace elements in petrochemical products. Analytical and bioanalytical chemistry. 2011;399(2):927-33.

Potts PJ, Ellis AT, Kregsamer P, Streli C, Vanhoof C, West M, Wobrauschek P. Atomic spectrometry update-X-ray fluorescence spectrometry. J Anal At Spectrom. 2006;21(10):1076–1107.

Abu-Alfa AK, Younes A. Tumor lysis syndrome and acute kidney injury: Evaluation, prevention, and management. Am J Kidney Dis. 2010;55(3):1–13.

Sevastos N, Theodossiades G, Archimandritis AJ. Pseudohyperka- lemia in serum: A new insight into an old phenomenon. Clin Med Res. 2008;6(1):30-32.

Niederhuber John E, Armitage James O, Doroshow James H, Kastan Michael B, Tepper Joel E. Aebeloff's clinical oncology, fifth edition. Philadelphia: Elsevier Saunders; 2014.

Coiffier Bertrand, Riouffol Catherine. "Management of tumor lysis syndrome in adults". Expert Review of Anticancer Therapy. 2007;7(2):233–239.

Davidson MB, Thakkar S, Hix JK, Bhandarkar MD, Wong A, Schreiber MJ. "Pathophysiology, clinical consequences, and treatment of tumor lysis syndrome". Am. J. Med. 2004;116(8):546–54.

Bellinger G, Santoro D, Savica V. Emerging drugs for hyperphosphatemia. Expert Opin Emerg Drugs. 2007;12:355–65.

Maynar M, Grijota FJ, Siquier-Coll J, et al. Erythrocyte concentrations of chromium, copper, manganese, molybdenum, selenium and zinc in subjects with different physical training levels. J Int Soc Sports Nutr. 2020;(35).

Tinoco-Veras CM, Bezerra Sousa MS, Borges da Silva B, Franciscato Cozzolino SM, et al. Analysis of plasma and erythrocyte zinc levels in premenopausal women with breast cancer. Nutr Hosp. 2011;26(2):293-297.

Xiujuan Wu, Jing Tang, Mingjun Xie. Serum and hair zinc levels in breast cancer: A meta-analysis. Scientific Reports. 2015;5:12249.

Rihwa Choi, Min-Ji Kim, Insuk Sohn, Serim Kim, Isaac Kim, Jai Min Ryu. Serum trace elements and their associations with breast cancer subgroups in Korean breast cancer patients. Nutrients. 2019:11:37.

Ding X1, Jiang M, Jing H, Sheng W, Wang X, Han J, Wang L. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China. Environ Sci Pollut Res Int. 2015; 22(10):7930-5.

Kotsopoulos J, Sukiennicki G, Muszynska M, Gackowski D, Kaklewski K, Durda K, Jaworska K, Huzarski T, Gronwald J, Byrski T, et al. Plasma micronutrients, trace elements, and breast cancer in brca1 mutation carriers: An exploratory study. Cancer Causes Control. 2012;23:1065–1074.

Siddiqui MK, Jyoti, Singh S, Mehrotra PK, Singh K., Sarangi R. Comparison of some trace elements concentration in blood, tumor free breast and tumor tissues of women with benign and malignant breast lesions: An indian study. Environ. Int. 2006;32:630–637.

Sharp P. The molecular basis of copper and iron interactions. Proc Nutr Soc. 2004;63(4):563- 569.

Lawrence DA. Heavy metal modulation of lymphocyte activities--II. Lead, an In vitro mediator of B-cell activation. Int J Immunopharmacol. 1981;3(2):153–161.

Choi R, Kim MJ, Sohn, Kim S, Kim I, Ryu JM, et al. Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in Lautech Osogbo, Nigeria. Indian J Cancer. 2015;52(1):106-9.

Adeoti ML, Oguntola AS, Akanni EO, Agodirin OS, Oyeyemi GM. Trace elements; copper, zinc, and selenium, in breast cancer afflicted female patients in Lautech Osogbo, Nigeria. Indian J Cancer. 2015;52:106–9.

Silva MP, Tomal A, Pérez CA, Ribeiro-Silva A, Poletti ME. Determination of Ca, Fe, Cu and Zn and their correlations in breast cancer and normal adjacent tissues. X-Ray Spectrometry. 2009;38(2):103- 111.

De Guise S, Bernier J, Lapierre P, Dufresne MM, Dubreuil P, Fournier M. Immune function of bovine leukocytes after in vitro exposure to selected heavy metals. Am J Vet Res. 2000;61(3):339–344.

Xiao Ding, Meng Jiang, Luhua Wang. Analysis of serum levels of 15 trace elements in breast cancer patients in Shandong, China. Environmental Science and Pollution Research. 2015;(22):7930–7935.