Mi RNA's are a Novel Class of Regulatory Genes Associated with Kidney Disease
Eswara Rao Potagani *
Department of Biochemistry, Great Eastern Medical School & Hospital, Srikakulam, Andhra Pradesh, India.
D. Rajarajeshwari
Department of Biochemistry, Narayana Medical College, Nellore, Andhra Pradesh, India.
Laxmi Lalitha
Department of Biochemistry, Great Eastern Medical School & Hospital, Srikakulam, Andhra Pradesh, India.
R. Viswa Kumar
Department of Biochemistry, Narayana Medical College, Nellore, Andhra Pradesh, India.
M. Prasad Naidu
Government Medical College, Pulivendhula, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Micro RNA's have been associated with chronic kidney disease progression and mortality. However, mi RNA 223 and mi RNA 192 role in CKD is poorly evaluated.
Aim: The learning aims to find the part of mi RNA 223 and 192 in CKD patients.
Methods: A cross-sectional observational study that included 450 study subjects out of which, 400 were cases and 50 were controls. Biochemical parameters were assessed by ELISA and mi RNA expression levels were evaluated by quantitative PCR.
Results: It was found that mi RNA 223 and 192 were significantly increased in the advancing stages of CKD when compared to controls.
Conclusion: mi RNA 192 and mi RNA 223 can be used as diagnostic markers of CKD.
Keywords: Disease, progression, stages of kidney disease, expression