Prospects of Sea Anemone Peptides for Pharmacology
Margarita Monastyrnaya *
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 690022, Vladivostok, Russia.
Emma Kozlovskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 690022, Vladivostok, Russia.
*Author to whom correspondence should be addressed.
Abstract
It has been found that the genes of a number of protein components of sea anemone venoms underwent significant diversification in the course of evolution. The elucidation of the molecular mechanisms of sea anemone peptides interactions with targets let investigators in the last decade actively study the molecular organization and the functioning mechanisms of cytoplasmic membranes, the various types and subtypes of ion channels/receptors involved in the processes of perception, processing, intra- and intercellular signal transduction, both in a body physiological and pathological state. A short characteristic of the structure and functional activity of several classes of sea anemone peptide components, which have pronounced pharmacological potential, is presented in this mini-review.
Keywords: Coelenterates, sea anemone, biologically active peptides and polypeptides, protein toxins, molecular organization