Apo Lipoproteins A1 and B in Multidrug-Resistant Tuberculosis (MDR-TB)
Bahi Gnogbo Alexis *
Department of Clinical and Fundamental Biochemistry, Institut Pasteur de Côte D'Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte D'Ivoire and Laboratory of Biology and Heath, Université Félix Houphouët-Boigny (UFHB), Abidjan 01 BP V34 Abidjan 01, Côte d'Ivoire.
Bamba Abou
Laboratory of Biology and Heath, Université Félix Houphouët-Boigny (UFHB), Abidjan 01 BP V34 Abidjan 01, Côte d'Ivoire.
Aké-Edjème Angèle
Department of Clinical and Fundamental Biochemistry, Institut Pasteur de Côte D'Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte D'Ivoire and Laboratory of Biochemistry and Molecular Biology, Université Félix Houphouët-Boigny (UFHB), Abidjan 01, BP V34 Abidjan 01, Côte d'Ivoire.
N’Guessan A. Jean Luc
Department of Clinical and Fundamental Biochemistry, Institut Pasteur de Côte D'Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte D'Ivoire and Laboratory of Biology and Heath, Université Félix Houphouët-Boigny (UFHB), Abidjan 01 BP V34 Abidjan 01, Côte d'Ivoire.
Kouman A. Augustine
Laboratory of Biology and Heath, Université Félix Houphouët-Boigny (UFHB), Abidjan 01 BP V34 Abidjan 01, Côte d'Ivoire.
Djaman Allico Joseph
Department of Clinical and Fundamental Biochemistry, Institut Pasteur de Côte D'Ivoire (IPCI), 01 BP 490, Abidjan 01, Côte D'Ivoire and Laboratory of Biology and Heath, Université Félix Houphouët-Boigny (UFHB), Abidjan 01 BP V34 Abidjan 01, Côte d'Ivoire.
*Author to whom correspondence should be addressed.
Abstract
Aims: The medical management of multidrug-resistant tuberculosis (MDR-TB) has become a major public health issue. Apolipoproteins play a key role in lipoprotein metabolism such as the recognition of receptors involved in lipoprotein metabolism. Thus, the study of the inter- relationships between apolipoproteins (A1 and B) and MDR-TB could represent an important approach to the biological management of MDR-TB patients.
Methodology: This is an experimental study carried out on eighty-two (82) patients including thirty-eight (38) MDR-TB patients which age ranged from 18 to 60 years old recruited from three tuberculosis centers (CAT) in the city of Abidjan and forty-four (44) non-tuberculosis patients used as control aged 18 to 60 years old recruited at the National Blood Transfusion Center (CNTS) in Treichville (Abidjan, Côte d’Ivoire). Total cholesterol, HDL-cholesterol and triglycerides were measured by the colorimetric-enzymatic method. Apolipoproteins A1 and B were measured using the immunoturbidimetric method.
Results and Conclusion: Showed a dyslipidemia concerning cholesterol and its HDL fraction, triglycerides and apolipoproteins A1 and B suggest an atherogenic profile in multidrug-resistant TB patients.
Keywords: MDR-TB, apolipoproteins, lipids, Abidjan, Côte d’Ivoire