Erythropoietin and the Role of Inflammation in Anaemia in Patients with Chronic Renal Living in Cote D’ivoire
Maxime Roméo Kouadio *
Department of Clinical and Fondamental Biochemistry, Institute Pasteur of Côte d’Ivoire, (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Health Biology Laboratory, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire.
Lydie Boyvin
Department of Clinical and Fondamental Biochemistry, Institute Pasteur of Côte d’Ivoire, (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire.
Gnogbo Alexis Bahi
Department of Clinical and Fondamental Biochemistry, Institute Pasteur of Côte d’Ivoire, (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire.
Valère Ultrich Tchokothe Tchako
Health Biology Laboratory, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire.
Gervais Melaine M’Boh
Department of Clinical and Fondamental Biochemistry, Institute Pasteur of Côte d’Ivoire, (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire.
Appolinaire Gnionsahé
Department of Nephrology, UFR Medical Sciences, University Félix Houphouet-Boigny, 01 BP V 34, Abidjan 01, Côte d’Ivoire.
Allico Joseph Djaman
Department of Clinical and Fondamental Biochemistry, Institute Pasteur of Côte d’Ivoire, (IPCI), 01 BP 490, Abidjan 01, Côte d’Ivoire and Health Biology Laboratory, University Félix Houphouët-Boigny (UFHB), 01 BP V34, Abidjan 01, Côte d’Ivoire.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Anemia is one of the most common complications of kidney failure. The kidney is responsible for the production of erythropoietin, a key hormone in erythropoiesis. Insufficient production of erythropoietin due to impaired kidney functions and also inflammation could explain this anemia. This study aimed at contributing to a better understanding of the mechanisms of erythropoietin in anemia observed in kidney failure.
Methods: The study population consisted of 138 people: 92 with chronic renal failure (46 not on dialysis, 46 on hemodialysis) and 46 voluntaries as control without kidney failure. Serum concentrations of urea, creatinine, C-reactive protein (CRP), serum iron, ferritin and transferrin were determined using the Cobas C311 Hitachi machine. The erythropoietin assay was performed on the ELISA chain.
Results: Lower mean values of EPO, increased CRP and decreased iron were observed in CKF patients (EPO: 5.66 ± 0.97 mIU / L; CRP: 45 ± 7.46 mg / l ; Iron: 12.46 ± 0.85 µmol / l), and patients under dialysis (EPO: 9 ± 0.51 mIU / L; CRP: 9 ± 2.66 mg / l; Iron: 10.07 ± 0.54 µmol / l) compared to controls (EPO: 18 ± 1.29 mIU / L; CRP: 2 ± 0.30 mg / l; Iron: 15.85 ± 0.56 µmol / l).
Conclusion: Anemia in chronic renal failure is thought to be due to an erythropoietin deficiency but also to an exacerbation of inflammation with a disruption of the iron status.
Keywords: Anemia, chronic kidney failure, Côte d’Ivoire, erythropoietin, inflammation