Phenolic Content, Antioxidant Activity, 15-Lipoxygenase and Lipid Peroxidase Inhibitory Effects of two Medicinal Plants from Burkina Faso: Acacia macrostachya Reich. Ex Benth (Mimosaceae) and Lepidagathis anobrya NEES (Acanthaceae)
Adjaratou C. Coulibaly *
Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso and Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
W. L. M. Esther B. Kabré
Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso and Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Mariam N. Traoré
Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso and Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Tata K. Traoré
Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso and Laboratoire du Développement desMédicaments (LADME), Ecole Doctorale de la Santé, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.
Nouhoun Nignan
Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso and Laboratoire du Développement desMédicaments (LADME), Ecole Doctorale de la Santé, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.
Noufou Ouédraogo
Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
Martin Kiendrebeogo
Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso.
Richard W. Sawadogo
Laboratoire de Biochimie et Chimie Appliquée (LABIOCA), Ecole Doctorale Sciences et Technologie, Université Joseph KI-ZERBO, 03 BP 7021 Ouagadougou 03, Burkina Faso and Institut de Recherche en Sciences de la Santé (IRSS), 03 BP 7192 Ouagadougou 03, Burkina Faso.
*Author to whom correspondence should be addressed.
Abstract
Acacia macrostachya (Mimosaceae) and Lepidagathis anobrya (Acanthaceae) are two medicinal plants used in Burkina Faso folk medicine for the treatment of inflammatory diseases. The purpose of this study was to assess the phenolic content, the antioxidant, lipoxygenase and lipid peroxidaseinhibitory effects of Acacia macrostachya and Lepidagathis anobrya.The experimental results revealed that Acacia mascrostachya and Lepidagathis anobrya have respective total phenolic contents varies from 240.13 ± 0.44 and 30.88 ± 0.30 mg GAE / 100 mg extract; and total flavonoids contents of 2.30 ± 0.002 and 4.24 ± 0.28 QE / 100 mg of extract. The two plants demonstrated anti-free radicals (ABTS) capacities of 0.06 and 0.14 TEAC while the FRAP reducing power of 2.24 ± 0.08 and 4.43 ± 0.12 mmol AAE per 100 mg respectively. Acacia macrostachya and Lepidagathis anobrya showed significant inhibitory effect on lipid oxidation with the inhibition percentage values of 55.45 ± 1.48 and 66.36 ± 0.65 respectively. In the 15-lipoxygenase inhibition, Acacia macrostachya demonstrated very important inhibitory effect with the IC50 value of 1.32 ± 0.16 while the effect of Lepidagathis anobrya is very moderate.The results of this work demonstrated the interest of Acacia macrostachya and Lepidagathis anobrya in the management of inflammatory diseases.
Keywords: Acacia macrostachya, Lepidagathis anobrya, antioxidant, 15-lipoxygenase, lipid peroxidase.