Serum Levels of Adenosine Deaminase and Insulin in Type 2 Diabetes Mellitus
Yengkhom Upen Singh
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Sangeeta Noarem
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Potsangbam Jenny Devi *
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Victoria Kshetrimayum
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Racheal Sweet Marbaniang
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Uma Debbarma
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
Ksh. Birendra Singh
Department of Medicine, Regional Institute of Medical Sciences, Imphal, India.
Maisnam Amuba Singh
Department of Biochemistry, Regional Institute of Medical Sciences, Imphal, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: To estimate the levels of serum adenosine deaminase and insulin in patients with type 2 diabetes mellitus and healthy subjects and to find the correlation between serum adenosine deaminase and serum insulin in type 2 diabetes mellitus.
Study Design: Case-control study.
Place and Duration of the Study: Department of Biochemistry and Department of Medicine, Regional Institute of Medical Sciences (RIMS), Imphal, Manipur between October 2017 to September 2019.
Methodology: 40 cases of type 2 diabetes mellitus were recruited from the Medicine Outpatient Department, RIMS and 40 healthy controls of age and sex-matched were recruited from those who came for a routine health check-up. Serum adenosine deaminase was measured by the calorimetry method and serum insulin was measured by ELISA method. The data were analyzed using statistical tools like Chi-square test, Independent sample t-test, Pearson’s Correlation through SPSS 21.0.
Results: Mean serum adenosine deaminase was (38.97±8.853)U/L in cases and (20.05±5.309)U/L in controls and it was statistically significant (P<0.001). Mean serum insulin in cases was found to be (18.09±5.554) μIU whereas in controls, it was (9.06±2.509) μIU which is statistically significant (p<0.001). Serum adenosine deaminase and insulin were found to be positively correlated to each other (r= 0.956, p<0.001).
Conclusion: Serum adenosine deaminase and serum insulin were significantly increased in type 2 diabetes mellitus and positively correlated to each other. Serum adenosine deaminase may be used as a prognostic marker for the pathogenesis of type 2 diabetes mellitus.
Keywords: Adenosine deaminase, type 2 diabetes mellitus, insulin, fasting blood sugar