Assessment of Cardiovascular Disease Risk in Prediabetes
Ashish Agarwal
Department of Biochemistry, GS Medical College and Hospital, Pilkhuwa, U.P., India.
Anupama Hegde *
Department of Biochemistry, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
Afzal Ahmad
Department of Biochemistry, GS Medical College and Hospital, Pilkhuwa, U.P., India.
Charu Yadav
Department of Biochemistry, Lady Harding Medical College, New Delhi, India.
Poornima A. Manjrekar
Department of Biochemistry, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
M. S. Rukmini
Department of Biochemistry, Kasturba Medical College, Mangalore, MAHE, Karnataka, India.
*Author to whom correspondence should be addressed.
Abstract
Introduction: Prediabetes is associated with dysglycemia, endothelial dysfunction, obesity and inflammation, placing them at an increased risk of cardiovascular events.
Aims: The present study aimed to investigate the risk of cardiovascular disease associated with prediabetes by estimation of serum interleukin-6, myeloperoxidase and urine microalbumin and their correlation with fasting plasma glucose and anthropometric measurements.
Study Design: Cross sectional study.
Place and Duration of Study: Study was conducted at Department of Biochemistry, Kasturba Medical College Hospitals, Mangaluru between 2014 and 2015.
Methodology: Eighty subjects were categorised into prediabetes and healthy controls based on their fasting plasma glucose values. Anthropometric data (weight, body mass index, waist circumference, hip circumference and waist-to-hip ratio from all subjects were recorded. Interleukin-6 & myeloperoxidase were estimated in serum sample whereas microalbumin was estimated in random urine sample.
Results: The mean anthropometric measurements and cardiovascular disease risk markers (interleukin-6, myeloperoxidase and urine microalbumin) were found to be significantly higher (p < 0.05) in prediabetes group. Myeloperoxidase had significant correlation with fasting plasma glucose (r-0.388) in the prediabetes group. Interleukin-6 and myeloperoxidase also showed a positive correlation with body mass index (r - 0.339, r - 0.327), waist circumference (r - 484, r - 0.493) and waist-to-hip ratio (r - 0.430, r - 0.493) while urine microalbumin did not correlate with fasting plasma glucose and anthropometric measurements in prediabetes group.
Conclusion: This study suggests that prediabetes is associated with central adiposity and have an increased risk for cardiovascular disease.
Keywords: Interleukin-6(IL-6), Myeloperoxidase (MPO), Microalbuminuria (MA), cardiovascular risk, prediabetes.