Acute Phase Reactant Profile of Subjects with Prediabetes and Type 2 Diabetes Mellitus
N. Chandrika *
Department of Biochemistry, Chamarajanagar Institute of Medical Sciences, Chamarajanagar, India.
S. M. R. Usha
Department of Biochemistry, Rajarajeswari Medical College and Hospital, Bengaluru, India.
*Author to whom correspondence should be addressed.
Abstract
Aim: The aim of the study is to examine the acute phase reactants in the backdrop of insulin resistance represented by prediabetic and overt diabetic states.
Study Design: Cross sectional study
Place and Duration of the Study: The study was undertaken at Rajarajeswari Medical college and Hospital, Bengaluru for around six months between July 2013 and December 2013.
Methodology: The study consists of three groups. We incorporated the World health organisation criteria for the diagnosis of prediabetes and type 2 diabetes mellitus. Accordingly forty seven adults were included in the first prediabetic group, the second group comprised of thirty seven type 2 diabetes mellitus patients. Thirty age and sex matched healthy volunteers constitued the third group. We intend to study High sensitive C reactive protein, serum albumin and serum uric acid levels, estimated by standard methods in the three groups.
Results: The Mean and standard deviation of HsCRP in prediabetic, T2DM and controls are 4.09±1.29, 3.38±1.41 and 1.68±0.51 mg//L respectively (p=0.030) in the present study. The serum albumin levels exhibit a statistically significant (p=0.001) downward trend from 4.67±0.49 g/dl in the healthy controls to 4.01±0.44 g/ dl in prediabetics and 3.96±0.55 g/dl in diabetics. We have not noticed any statistically significant difference in the levels of uric acid among the three groups.
Conclusion: The acute phase reactant profile corresponds to the inflammatory environment and worsens as the disease progresses, in a metabolic disorder like T2DM, which is apparently evident in our study.
Keywords: Acute phase reactants, prediabetes, type 2 diabetes mellitus, inflammation