Evaluation of Anti-Inflammatory Activities of Aqueous and Ethanolic Extracts of Gomphrena celosioides Linn.
Gogahy Konan
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
Aka Ayebe Edwige
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
Yeo Dodehe
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
J. Djaman Allico
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
F. Yapo Adou
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
D. N’guessan Jean
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
F. Yapi Houphouet *
Laboratory of Biochemical, Pharmacodynamics, UFR Biosciences, University of Cocody, Abidjan, 22 BP 1679 Abidjan 22, Ivory Coast
*Author to whom correspondence should be addressed.
Abstract
Aims: This study was therefore aimed to evaluate potential anti-inflammatory activity of Aqueous and Ethanolic extracts of Gomphrena celosioides (C. Mart) and to determine the most active extract in rat.
Study Design: Gomphrena celosioides was collected from Bingerville, District of Abidjan (Cote d’Ivoire). The plant was identified and authenticated by the “Centre National de Floristique”, University Felix Houphouet Boigny, Cocody.
Place and Duration of Study: Analysis on the plant samples were done at the ‘’Laboratoire de Pharmacodynamie-Biochimique, UFR Biosciences, Université de Cocody-Abidjan (Côte d’Ivoire), and Institut Pasteur de Côte d’Ivoire, Département de Biochimie médicale & fondamentale’’ between September 2013 and June 2014.
Methodology: The anti-inflammatory activities were investigated by utilizing carrageenan induced paw edema and CRP concentration in rat. These extracts were administrated intraperitoneally at differents doses (100 and 200mg/kg body weight) to rats.
Result: The present study showed a significant anti-inflammatory activity at 200mg/kg. b.w. to both extracts which were comparable to the Diclofenac (10mg/kg) inhibition.
However, the inflammation inhibition is raised more than 2.6% with the ethanolic extract when this comparison is made with the aqueous extract. This study showed an increased CRP concentration (p <0.05) at rats treated with carrageenan with regard to extracts and Diclofenac rats groups.
But there is no significant difference between CRP concentration with extracts and diclofenac rats groups (p>0.05).
Conclusion: This study showed that aqueous and ethanolic extracts of Gomphrena celosioides have a potential anti-inflammatory properties. However, this anti-inflammatory activity is more raised with ethanolic extract and seems to have the most active extract. So, ethanolic and aqueous extracts can be utilized for therapeutic purposes.
Keywords: Gomphrena celosioides, anti-inflammatory, carrageenan, diclofenac, CRP