A Comparative Study of High Sensitive C-Reactive Protein (hs-CRP) and Urinary Calcium/Creatinine Ratio in Normal Pregnancy and Pregnancy Induced Hypertension in Gujarat, India
Smita N. Vasava
Department of Biochemistry, SBKS Medical Institute and Research Center, Piparia, Gujarat, India
Amitkumar V. Maheshwari *
Department of Biochemistry, Gujarat Adani Institute of medical Sciences, Bhuj, India
Subhankar Kayal
Department of Biochemistry, Rampurhat Government Medical College and Hospital, Rampurhat, West Bengal, India
Jagruti Dholakiya
Department of Biochemistry, Government Medical College, Bhavnagar, India
Kedar Mehta
Department of Community Medicine, GMERS Medical College, Gotri, India
Hariom Sharma
Department of Biochemistry, Government Medical College, Bhavnagar, India
*Author to whom correspondence should be addressed.
Abstract
Background: Pregnancy-induced hypertension (PIH) is a condition characterized by high blood pressure during pregnancy. It is the most common leading cause of maternal and perinatal morbidity and mortality in females. Serum high sensitive C-reactive protein (hs-CRP) is one of the suitable markers for low grade inflammation evaluation. Urinary calcium-creatinine ratio (UCa/Cr) is a valuable marker for prediction of PIH.
Aim: To measure & correlate serum hs-CRP and urinary calcium-creatinine ratio in between pregnancy-induced hypertension and normal pregnancy.
Material & Methods: In present study total 150 subjects attending Department of Obstetrics & Gynecology at Sir Takhtsinhji Hospital, Bhavnagar, Gujarat, were included which were categorized in two groups. Group A: 75 patients of pregnancy-induced hypertension; Group B: 75 normal pregnant women as a control group. They were primarily diagnosed based on measurement of blood pressure, clinical examination followed by biochemical investigations like hs-CRP, urinary calcium & creatinine, RBS, urea, creatinine, uric acid, CK-MB. Written informed consent was obtained from all participants before enrolling in the study.
Results: No significant change in the levels of biological parameters like RBS, urea, creatinine and CK-MB was observed in both the study groups (p>0.05) except serum uric acid shows a significant difference (p<0.001). The levels of hs-CRP were found to be significantly higher in patients of pregnancy-induced hypertension (7.81±3.681)as compared to the normal pregnant women (3.11±1.972)(p<0.0001) .UCa/Cr ratio had more sensitivity and specificity than hs-CRP for prediction of pregnancy-induced hypertension compared to normal pregnancy.
Conclusion: UCa/Cr ratio can be used as a more sensitive and specific test to detect pregnancy induced hypertension.
Keywords: Hs-CRP, urinary calcium creatinine ratio, pregnancy induced hypertension