α-Klotho as A Novel Biomarkers in Chronic Diabetic Nephropathy

Main Article Content

Mohy Eldin Abd EL-Fattah
Taghrid B. El-abaseri
Hegazy Mohamed Abd Elaziz Mohamed

Abstract

Background: Type 2 diabetes mellitus (DM) is the most common cause of end- stage renal disease. Albuminuria is the foremost commonly utilized marker to anticipate onset of diabetic nephropathy (DN) without sufficient affectability and specificity to identify early DN.

Aim: This study aimed to evaluate plasma α-Klotho as a new biomarker for chronic diabetic nephropathy.

Methods: This cross sectional study included 125 Egyptian subjects attending the out Patients Clinic of the Department of Internal Medicine, 10Th of Ramadan city Health Insurance Hospital and divided into:-control group, patient with diabetic mellitus, patients with Diabetic nephropathy and patient with diabetic nephropathy and other complications. Patients were subjected to measurement of plasma α- Klotho, FBS, HbAIC, serum creatinine, serum urea, serum uric acid, k, Na, serum phosphorus, Albumin: Creatinine Ratio, GFR, Chol, TG, LDL HDL, AST, ALT, T.BIL, D.BIL ALB, TP, GLB and A/G ratio.

Results: Results showed that plasma a-klotho was significantly correlated with hemoglobin A1C, potassium, GFR, Albumin, TP and GLB. Meanwhile, plasma a- klotho was negatively correlated with duration of DM, CR, Urea, UR.A, Na, phosphorus, ACR, Chol, TG, LDL, AST, ALT, T.BIL, and D.BIL. However, there were no significant correlations between plasma α -klotho and FBS, HDL and A/G

ratio. At cut-off level ≥2.6, plasma α -klotho had 95% sensitivity and 81% specificity for diagnosing diabetic nephropathy.

Conclusion: α-klotho may be the chronic diabetic nephropathy markers for predicting renal injury in patients with type 2 diabetes.

Keywords:
α-kloth, DN.

Article Details

How to Cite
EL-Fattah, M. E. A., El-abaseri, T. B., & Mohamed, H. M. A. E. (2020). α-Klotho as A Novel Biomarkers in Chronic Diabetic Nephropathy. International Journal of Biochemistry Research & Review, 29(10), 53-62. https://doi.org/10.9734/ijbcrr/2020/v29i1030237
Section
Original Research Article

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