Main Article Content
Aims: The aim of this study was to find the correlation between serum sodium and serum potassium with preeclampsia.
Study Design: This is a cross sectional study.
Place and Duration of Study: Conducted in Department of Biochemistry in collaboration with the Department of Obstetrics and Gynaecology, (RIMS), Imphal (Manipur) from September 2016 to August 2018.
Methodology: Blood samples of 30 diagnosed patients of preeclampsia and above 18 years of age admitted in the obstetrics antenatal ward of RIMS, Imphal was taken. Samples were analysed for serum sodium and potassium by randox rx imola autoanalyser. The data were analyzed using statistical tools like Chi-square test through SPSS 21.0.
Results: Serum sodium levels were high in 63.34%of study group, low levels were seen in 3.33% followed by normal levels in 33.3%of study group. Serum potassium levels were low in 56.6%of study group, normal in 40% and high in 3.33% of study group. There was positive correlation between serum sodium and proteinuria which was statistically significant at P-value <0.01 and negative correlation was seen between serum potassium levels with proteinuria which was statistically significant at P-value 0.04.
Conclusion: In this study hypernatremia and hypokalaemia were associated with preeclampsia, and may have important causative role in this syndrome therefore constant monitoring of serum sodium and potassium level in pregnant women may help in early detection, management and prevention of preeclampsia.
Davey DA, MacGillivray I. The classification and definition of the hypertensive disorders of pregnancy. Am J Obstet Gynecol. 1988;158(4):892-898.
Prafula KM. Evaluation of serum electrolytes in preeclamptic pregnant women: A hospital based study. Global Journal for Research Analysis (GJRA). 2017;6(5):122-23.
Villar J, Say L, Gulmezoglu AM, Marialdi M, Lindheimer MD, Betran AP et al. Pre-Eclampsia Eclampsia: A Health Problem for 2000 Years. In: Critchly H, MacLean A, Poston L and Walker J Eds. Preeclampsia RCOG Press London. 2003;1:189-207.
Cunningham, FG, Gant NF, Leveno KJ, Gilstrap III LC, Hauth JC and Wenstrom KD (eds): Williams Obstetrics and Gynecology 23rd ed. USA: McGraw Hill Companies. 2014;728.
Indumati K, Kodliwadmath MV, Sheela MK. The Role of serum Electrolytes in Pregnancy induced hypertension. Journal of Clinical and Diagnostic Research. 2011;5(1):66-69.
O’Shaughnessy KM, Karet FE. Salt handling and hypertension. J Clin Invest. 2004;113:1075-81.
Tietz NW. Textbook of Clinical Chemistry. 1st ed. Philadelphia: WB Saunders Company; 1986.
Sunitha T, Sameera K, Umaramani G. Study of Biochemical changes in Preeclamptic women. International Journal of Biological & Medical Research. 2012; 3(3):2025-2028.
Anjum KS, Alka NS. Electrolyte Status in Preeclampsia. Online Internat Interdiscip Res J. 2013;3:30-36.
Joanne Marie A, Paulino-Morente, Ireene G Cacas-David, Vaneza L Penolio. Association of hypokalemia and preeclampsia and correlation of levels of serum potassium to blood pressure severity in preeclampsia. Philippine Obstetrical and Gynecological Society (Foundation) Inc (POGS). 2018;42(2):9-16.
Magna M, Sitikanta N. Serum electrolyte levels in preeclamptic women: A comparative study. International Journal of Pharma and Bio Sciences. 2012;3(2):572-78.
Tabassum H, Al-Jameil, Ali MN, Khan FA, Al-Rashed M. Status of serum electrolytes in preeclamptic pregnant women of Riyadh, Saudi Arabia. Biomedical Research. 2015;26(2):219-224.
Jack H Kaplan. The sodium pump and hypertension: A physiological role for the cardiac glycoside binding site of the Na,K-ATPase. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005;102(44):15723–15724.
Sullivan CA, Martin JN Jr. Sodium and pregnancy. Clin Obstet and Gynaec. 1994; 37(3):558-573.
Arumanayagam M, Rogers M. Platelet sodium pump and Na+ /K+ cotransport activity in non-pregnant, normotensive and hypertensive pregnant women. Hypertens Pregnancy. 1999;18(1):35-44.
Blaustein MP, Zhang J, Chen L, Hamilton BP. How does salt retention raise blood pressure. Am J Physiol Regul Integr Comp Physiol. 2006;290(1):514-523.
Guly LU, Fatma TO, Tuncay O, Ayse D. Changes in potassium clearance and plasma K levels in normal pregnancy. Journal of Academy of Sciences. 1992; 5(2):133-135.
Yussif MN, Salih MR, Sami AZ, Mossa MM. Estimation of serum zinc, sodium and potassium in normotensive and hypertensive primigravida pregnant women. Tikrit Medical Journal. 2009;15(1): 13-18.
Al-Balas M, Bozzo P, Einarson A. Use of diuretics during pregnancy. Can Fam Physician. 2009;55(1):44-45.
Shah S, Khatri I, Freis ED. Mechanism of antihypertensive effect of thiazide diuretics. Am Heart J. 1978;95(5):611-8.
Firas A Ghanem, Assad Movahed. Use of Antihypertensive Drugs during Pregnancy and Lactation. Cardiovascular Therapeutics The Authors Journal Compilation Blackwell Publishing Ltd. 2008;26(1):38–49.