Phenolic Content, Antioxidant Activity, 15-Lipoxygenase and Lipid Peroxidase Inhibitory Effects of two Medicinal Plants from Burkina Faso: Acacia macrostachya Reich. Ex Benth (Mimosaceae) and Lepidagathis anobrya NEES (Acanthaceae)

Main Article Content

Adjaratou C. Coulibaly
W. L. M. Esther B. Kabré
Mariam N. Traoré
Tata K. Traoré
Nouhoun Nignan
Noufou Ouédraogo
Martin Kiendrebeogo
Richard W. Sawadogo

Abstract

Acacia macrostachya (Mimosaceae) and Lepidagathis anobrya (Acanthaceae) are two medicinal plants used in Burkina Faso folk medicine for the treatment of inflammatory diseases. The purpose of this study was to assess the phenolic content, the antioxidant, lipoxygenase and lipid peroxidaseinhibitory effects of Acacia macrostachya and Lepidagathis anobrya.The experimental results revealed that Acacia mascrostachya and Lepidagathis anobrya have respective total phenolic contents  varies from 240.13 ± 0.44 and 30.88 ± 0.30 mg GAE / 100 mg extract; and total flavonoids contents of 2.30 ± 0.002 and 4.24 ± 0.28 QE / 100 mg of extract. The two plants demonstrated anti-free radicals (ABTS) capacities of 0.06 and 0.14 TEAC while the FRAP reducing power of 2.24 ± 0.08 and 4.43 ± 0.12 mmol AAE per 100 mg respectively. Acacia macrostachya and Lepidagathis anobrya showed significant inhibitory effect on lipid oxidation with the inhibition percentage values of 55.45 ± 1.48 and 66.36 ± 0.65 respectively. In the 15-lipoxygenase inhibition, Acacia macrostachya demonstrated very important inhibitory effect with the IC50 value of 1.32 ± 0.16 while the effect of Lepidagathis anobrya is very moderate.The results of this work demonstrated the interest of Acacia macrostachya and Lepidagathis anobrya in the management of inflammatory diseases.

Keywords:
Acacia macrostachya, Lepidagathis anobrya, antioxidant, 15-lipoxygenase, lipid peroxidase.

Article Details

How to Cite
Coulibaly, A. C., Kabré, W. L. M. E. B., Traoré, M. N., Traoré, T. K., Nignan, N., Ouédraogo, N., Kiendrebeogo, M., & Sawadogo, R. W. (2020). Phenolic Content, Antioxidant Activity, 15-Lipoxygenase and Lipid Peroxidase Inhibitory Effects of two Medicinal Plants from Burkina Faso: Acacia macrostachya Reich. Ex Benth (Mimosaceae) and Lepidagathis anobrya NEES (Acanthaceae). International Journal of Biochemistry Research & Review, 29(8), 18-25. https://doi.org/10.9734/ijbcrr/2020/v29i830209
Section
Original Research Article

References

Higgs GA, Salmon JA, and Spayne JA. The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. Br Journal of Pharmacology.1981;74: 429–433.

Li J, Rao J, Liu Y, Cao Y, Zhang Y, Zhang Q, and Zhu D. 15 Lipoxygenase promotes chronic hypoxia-induced pulmonary artery inflammation via positive interaction with nuclear factor-κB. Arteriosclerosis Thrombosis Vascular Biology. 2013;33:971–979

Bartsch H, Nair J. Chronic inflammation and oxidative stress in the genesis and perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbeck’s Archives of Surgery. 2006;391(5):499–510

Kouamé JA. Etude des propriétéscytotoxiqueet antiradicalaire d'extrait de feuille et de galle de GuierasenegalensisJ.F.Gmel (Combretacea).Thèse de Doctarat. Université de Ouagadougoua (UFR/SDS); 2009.

Sawadogo WR, Meda A, Lamien CE, Kiendrebeogo M, Guissou IP. et Nacoulma OG. Phenolic content and antioxydant activity of six Acanthaceae from Burkina Faso. Journal of Biology and Sciences. 2006;6(2):249-252.

Nacoulma OG.Plantesmédicinalesetpratiquesmédicinalestraditionnelles au Burkina Faso - Cas du plateau central (Medicinal plants and traditional medical practices in Burkina Faso: the case of the central plateau), Université de Ouagadougou. Thèse de Doctoratd'Etat: Tome I. 1996;320-261.

Sawadogo WR, Maciuk A,Banzouzi JT, Champy P, Figadere B, Guissou IP, Nacoulma OG. Mutagenic effect, antioxidant and anticancer activities of six medicinal plants from BurkinaFaso, Natural Product Research. 2012;1-5.

Singleton VL, Orthofer R,Lamuela-Raventós RM. Analysis of total phenols and other oxidation substrates and antioxidants by means of folin-ciocalteu reagent. In Methods in Enzymology. 1999;299:152–178.

Arvouet-Grand A, Vennat B, Pourrat A, et Legret P. Standardisation d’un extrait de Propolis et identification des principauxconstituants. Journal de Pharmacie de Belgique. 1994;49:462-468:3(3):10p.

Re R, Pellegrini N, Poteggent A, Pannala A, Yang M. et Rice-Evans C.Antioxidant activity applying an improved ABTS radical cationdecolorization assay. Free Radical Biology and medicine. 1999;26(9/10):1231-1237.

Hinneburg I, Damien Dorman HJ,Hiltunen R. Antioxidant activities of extracts from selected culinary herbs and spices. Food Chemistry. 2006;97:122–129

Malterud KE, Rydland KM. Inhibitors of 15-lipoxygenase from orange peel. Journal of agricultural and food chemistry. 2009;48:5576-5580.

Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical biochemistry. 1979;95(2):351-8.

Sombié PEAD, Hilou A, CoulibalyAY, Tibiri A, Kiendrebeogo M, OGN. Brain protective and erythrocytes hemolysis inhibition potentials from galls of Guierasenegalensis JF Gmel (Combretaceae). Journal of pharmacology and toxicology. 2011;6(4):361-70.

Cibin TR, Srinivas G, Gayathri D, Srinivas P, Lija Y, Abraham A.Antioxidant and antiproliferative effects of flavonoids from Emilia sonchifolia Linn on human cancer cells. International Journal of Pharmacology. 2006;2:520–524.

Cioffi G, Dal Piaz F, De Caprariis P, Sanogo R, Marzocco S. Antiproliferative triterpenesaponins from Entadaafricana. Journal of Natural Products. 2006;69:1323–1329.

Liu J. Pharmacology of oleanolic acid and ursolic acid. Journal of Ethnopharmacology. 1995;49:57–68.

Rand RH, Faridah A, Ahmed SA, Fatemeh J, Fatimah AB, Zamberi S. A review: cancer research of natural products in Asia. International Journal of Cancer Research. 2009;5:69–82.

Ghedira K. Les flavonoïdes: Structure, proprieties biologiques, role prophylactique et emploisen thérapeutique. Phytothérapie. 2005;3:162-169.

Narayana KR, Reddy MS, Chaluvadi MR,Krishina DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian. Journal of pharmacology. 2001;(33):2-16.

Yenjai C, Prasanphen K, Daodee S, Wongpanich V, Kittakoop P. Bioactive flavonoids from Kaempferiaparviflora. Fitoterapia. 2004;75:89–92.

Middleton E, Kandaswami C, Theoharides T).The Effects of Plant Flavonoids on Mammalian Cells: Implications for Inflammation, Heart Disease, and Cancer. Pharmacological Reviews. 2000;52:673-751.

Chang CH, Lin CC, Hattori M, Namba T. Effects on anti-lipid peroxidation of Cudraniacochinchinensis var. gerontogea. Journal of ethnopharmacology. 1994;44:79-85.

Ouédraogo N, Lompo M, Sawadogo RW, Tibiri1 A, Hay AE, Koudou J, Dijoux M-g, Guissou IP. Étude des activités anti-inflammatoire, analgésiqueetantipyrétique des décoctésaqueux des feuilles et des racines de PterocarpuserinaceusPoir. (Fabaceae), Phytothérapie Springer-Verlag France; 2011.

Gil B, Sanz MJ, Ferrándiz MC, et al. Accelerated communication: Effects of flavonoids on Naja and human recombinant synovial phospholipases A2 and inflammatory responses in mice. Life Science. 1994;54(20):PL333-PL338.

Havsteen BH. The biochemistry and medical significance of the flavonoids. Journal of Pharmacology and Therapeutics. 2002;96:67-202

Bruneton J. Pharmacognosie, Phytochimie, Plantesmédicinales. (4th edn). Lavoisier Tec & Doc: Paris; 2009.

Zhou HC, Lin YM, Wei SD, Tam N-Y. Structural diversity and antioxidant activity of condensed tannins fractionated from Mangosteen pericarp. Food Chemistry. 2011;129:1710-1720.

Sawadogo WR, Lompo M, Somé N, Guissou IP, Nacoulma-Ouedraogo OG. Anti-inflammatory, analgesic and antipyretic effects of Lepidagathis anobrya Nees (Acanthaceae). African Journal of Traditional, Complementary and Alternative Medicines 8; 2011.

Viana GSB, Bandeira MAM, Moura LC, Souza-Filho MVP, Matos FJA, Ribeiro RA. Analgesic and Antiinflammatory Effects of the Tannin Fraction from Myracrodruonurundeuva Fr. All. Phytotherapy Research. 1997;11:118-122.