Assessment of Leptin and Prolactin in Women with Polycystic Ovarian Syndrome
International Journal of Biochemistry Research & Review,
Background: Polycystic ovary syndrome (PCOS) is one of the most frequent endocrine disorders among women at reproductive age and is characterized by infertility, hirsutism, obesity, insulin resistance, and menstrual irregularities. Leptin, an adipocyte derived hormone, serves as a link relaying metabolic signals to the neuronal networks in the brain to modulate hypothalamo-pituitary- ovarian axis. Circulating leptin correlates strongly with obesity, which is frequently associated with PCOS. PCOS is associated with hyperandrogenemia and relatively high estrogen levels, which could stimulate prolactin secretion.
Aims: 1. To assess serum leptin and prolactin in women with PCOS and to compare them with healthy women as controls. 2. To correlate the leptin, prolactin and body mass index (BMI) among a group of PCOS women and healthy women as controls.
Methodology: The study was conducted at Kempegowda Institute of Medical Sciences & Hospital, Bangalore. A comparative study was conducted which includes 30 women who has diagnosed with PCOS and 30 healthy women with as controls. The age group for the study was 18 to 35 years. Fasting blood samples were drawn to measure serum leptin and prolactin. BMI was also calculated. Interpretation of data was done using SPSS version 13.
Results: Significant positive correlations between leptin levels and BMI in cases and controls (ρ= 0.683, p < 0.001; ρ= 0.485, p = 0.007 respectively) were observed. Mean BMI, leptin and prolactin were found elevated in the PCOS women compared to controls but they were not statistically significant. No significant correlation was found between leptin and prolactin.
Conclusion: Leptin levels were correlated with BMI both in PCOS women and in the healthy controls. Leptin may not have a direct role in the pathogenesis of PCOS, as the serum levels were not significantly higher in PCOS women and did not correlate with prolactin.
- Body mass index
- polycystic ovarian syndrome
How to Cite
Carolyn J. Alexander, Edward P. Tangchitnob, Norman E. Lepor. Polycystic ovary syndrome: A major unrecognized cardiovascular risk factor in women. Med Reviews. 2009;2(4).
Andrea Dunaif, Jinru Xia, Carol-Beth Book, Esther Schenker, Zhichun Tang. Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle: A potential mechanism for insulin resistance in the polycystic ovary syndrome. J. Clin. Invest. 1995;96: 801-10.
Pikee Saxena, Anupam Prakash, Aruna Nigam, et al. Polycystic ovary syndrome: Is obesity a sine qua non? A clinical, hormonal, and metabolic assessment in relation to body mass index. Indian J Endocr Metab. 2012;16(6):996-9.
Chakrabarti J. Serum leptin level in women with polycystic ovary syndrome: Correlation with adiposity, insulin, and circulating testosterone. Ann Med Health Sci Res. 2013;3(2):191–196.
Nasser M. Rizk, Elham Sharif. Leptin as well as free leptin receptor is associated with polycystic ovary syndrome in young women. International Journal of Endocrinology. 2015;1-10.
Jalilian N, Haghnazari L, Rasolinia S. Leptin and body mass index in polycystic ovary syndrome. Indian J Endocr Metab. 2016;20:324-8.
Zadeh-Vakili A, Tehrani FR, Hashemi S, Amouzegar A, Azizi F. Relationship between sex hormone binding globulin, thyroid stimulating hormone, prolactin and serum androgens with metabolic syndrome parameters in Iranian women of reproductive age. J Diabetes Metab. 2012;S2:008.
Dorte Glintborg, Magda Altinok, et al. Prolactin is associated with metabolic risk and cortisol in 1007 women with polycystic ovary syndrome. Human Reproduction. 2014;29(8):1773–79.
Soodabeh Zandi, Saeideh Farajzadeh, Hamideh Safari. Prevalence of polycystic ovary syndrome in women with acne: Hormone profiles and clinical findings. Journal of Pakistan Association of Dermatologists. 2010;20:194-198.
Dinka Pavicic Baldania, Lana Skrgatica, et al. Altered leptin, adiponectin, resistin and ghrelin secretion may represent an intrinsic polycystic ovary syndrome abnormality. Gynecological Endocrinology. 2019;35(5):401–5.
Azhar Mohammad Nomair, Nisreen K. Aref, et al. Serum leptin level in obese women with polycystic ovary syndrome, and its relation to insulin resistance. Asian Pacific Journal of Reproduction. 2014;3(4): 288-94.
Olszanecka-Glinianowicz M, Madej P, Nylec M, Owczarek A, Szanecki W, Skalba P, et al. Circulating apelin level in relation to nutritional status in polycystic ovary syndrome and its association with metabolic and hormonal disturbances. Clin Endocrinol (Oxf). 2013;79:238–42.
Ramanand SJ, Ramanand JB, Jain SS, Raparti GT, Ghanghas RR, Halasawadekar NR, Patil PT, Pawar MP. Leptin in non PCOS and PCOS women: A comparative study. Int J Basic Clin Pharmacol. 2014;3:186-93.
Tayfun Alper, Hakki Kahraman, Mehmet Bilge Cetinkaya, Filiz Yanik, Gulizar Akcay, Abdulkerim Bedir, et al. Serum leptin and body composition in polycystic ovarian syndrome. Ann Saudi Med. 2004;24(1):9-12.
Goyal A, Ganie M. Idiopathic hyperprolactinemia presenting as polycystic ovary syndrome in identical twin sisters: A case report and literature review. Cureus. 2018;10(7):e3004.
Hana Fakhoury, Hani Tamim, et al. Age and BMI adjusted comparison of reproductive hormones in PCOS. J Family Med Prim Care. 2012;1(2):132–136.
Michael T. Sheehan. Polycystic ovarian syndrome: Diagnosis and management. Clinical Medicine & Research. 2004;2(1): 13-27.
Ansam A. Al-Bayatti. Insulin resistance and upper-body obesity in polycystic ovary syndrome. Middle East Fertility Society Journal. 2006;11(3):202-9.
Zacur HA, Foster GV. Hyperprolactinemia and polycystic ovary syndrome. Semin Reprod Med. 1992;10:236-245.
Kumar AN, Naidu JN, Satyanarayana U, Ramalingam K, Anitha M. Metabolic and endocrine characteristics of Indian women with polycystic ovary syndrome. Int J Fertil Steril. 2016;10(1):22-28.
Kamal Eldin Ahmed Abdelsalam, Waleed Ibrahim. Relationship between TSH, T4, T3 and Prolactin in overweight and lean Sudanese PCOS patients. International Journal of Biomedical Research. 2015; 6(02):108-112.
Hernandz I, Parra A, et al. Hypothalamic dopaminergic tone and prolactin bioactivity in women with polycystic ovary syndrome. Archives of Med. Rese. 2000;31:216-222.
Shibli-Rahhal A, Schlechte J. The effects of hyperprolactinemia on bone and fat. Pituitary. 2009;12:96-104.
Kate E. Therkelsen, Tobin M. Abraham, et al. Association between prolactin and incidence of cardiovascular risk factors in the Framingham heart study. Journal of the American Heart Association. 2016;115: 1-10.
Pala NA, Laway BA, Misgar RA, Shah ZA, Gojwari TA, Dar TA. Profile of leptin, adiponectin, and body fat in patients with hyperprolactinemia: Response to treatment with cabergoline. Indian J Endocr Metab. 2016;20:177-81.
Roelfsema F, Pijl H, Keenan DM, Veldhuis JD. Prolactin secretion in healthy adults is determined by gender, age and body mass index. PLoS ONE. 2012;7(2):e31305.
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