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This study was carried out to investigate the immune modulatory properties of different graded stored powdered of Telfairia occidentalis supplemented diet on male wistar rats. Twelve male wistar rats weighing 120g±20g were purchased, acclimatised and randomly allotted into four (T1, T2, T3, T4) Telfairia occidentalis supplemented groups (0% 5%, 10% and 15%). The rate of their feeding was monitored for three weeks after which the animals were decapitated and the blood and organs were removed for haematological and endogenous antioxidant analysis. The result showed that the highest feed intake was observed in animal fed with the highest level of Telfairia occidentalis supplementation. Also from the haematological analysis, the white blood cell of the highest supplementation was boosted when compared to other graded level likewise the endogenous Antioxidant level was enhanced when compared with the control group.