International Journal of Biochemistry Research & Review

Background and Objectives: Polycystic ovarian disease (PCOS) is probably the most prevalent endocrinological disorder affecting females and is the most common cause of menstrual disturbance during the reproductive age. It is characterized by polycystic ovaries on ultrasound and/or clinical and biochemical signs and symptoms of hyperandrogenism and/or oligo- anovulation. Therefore, this study was designed to determine relationship among LH/FSH ratio, BMI and the clinical profile of females suffering from PCOS.

Materials and Methods: Blood samples from 50 study subjects were taken after getting informed consent for hormone profile (FSH and LH) by ELISA kit of Kamiya Biomedical company. Body Mass index (BMI) and Ultra-sonogram related findings of polycystic ovarian syndrome patients were recorded. Statistical analysis was done by using SPSS-20.

Results: LH/FSH values were significantly higher among infertile and fertile females (P=0.05). BMI was also significantly correlated statistically in female patients with and without hirsutism (P=0.005). BMI (P=0.00) and LH/FSH (P=0.004) were also found to be associated significantly with obesity in patients with PCOS.

Conclusion: Since FSH was significantly correlated with obesity and infertility while BMI was associated with obesity and hirsutism among the clinical profiles, lifestyle interventions to decrease the overweight and obesity would be able to reduce the unwanted clinical symptoms of infertility and hirsutism in females with polycystic ovary syndrome.