Effect of Co-administration of Chloroquine Phosphate and Cefuroxime Axetil on Serum Lipids and Lipid Peroxidation in Rats
O. E. Etim *
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
E. J. Akpan
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
M. I. Akpanabiatu
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
U. A. Akpan
Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Nigeria
*Author to whom correspondence should be addressed.
Abstract
There is scanty information on the response of biochemical system to the co-administration of anti-malarial drugs and antibiotics. This was what informed the need to undertake the present study. The effects of co-administration of chloroquine (CQ) and cefuroxime (CE) on serum lipids and lipid peroxidation in albino Wistar rats was investigated. Standard reagent kits were used for the assay. The study included assay for the effect of the co-administration of CQ and CE on high density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-C) and lipid peroxidation. The result revealed that the level of HDL-C was not affected by the co-administration. Those of TC, TG and LDL-C increased significantly (p<0.05) above the value obtained for the control group. Malondialdehyde (MDA) level increased significantly (p<0.05) in group treated with CQ in combination with CE. The present study has revealed that co-administration of chloroquine and cefuroxime tends to raise TC, TG, LDL-C and MDA levels. The result reveals that co-administration of chloroquine and cefuroxime may adversely affect the metabolism of lipids.
Keywords: Chloroquine, cefuroxime, serum lipids, lipid peroxidation