Serum C-reactive Protein in Psoriasis Vulgaris: A Case-control Study in a Tertiary Care Hospital from Southern India
Krishna Murari *
Department of Biochemistry, Gandhi Medical College, Bhopal, Madhya Pradesh, India
*Author to whom correspondence should be addressed.
Abstract
Aims: The present study was designed to assess the levels of serum C - reactive protein in different severity group of psoriasis vulgaris.
Study Design: Case-control study.
Place and Duration of Study: Clinically diagnosed and untreated psoriasis vulgaris patients are recruited from out patients department of Dermatology, J.J.M. Medical College, Davangere, Karnataka (India) from May 2015 to April 2016.
Methodology: A case control study was conducted on sixty clinically diagnosed and untreated cases of psoriasis vulgaris. Sixty age and sex matched healthy controls were also recruited from general population of Davangere, Karnataka. The psoriasis patients were divided into three groups mild, moderate, severe based on Psoriasis Area Severity Index. Venus blood sample was collected from each study subjects and analyzed for C - reactive protein by immunoturbimetric method.
Results: Mean serum C-reactive protein were found to be significantly (<0.001) higher in various severity groups of psoriasis (5.96 ± 3.96 mg/dl) as compare to healthy controls (0.28 ± 0.12 mg/dl).
Conclusion: Serum C-reactive protein may be useful immune marker to evaluate the severity of psoriasis and could be used to monitor psoriasis and its treatment.
Keywords: C - reactive protein, inflammation, psoriasis, PASI scores