Serum Cystatin C Profile in a Cohort of Patients with Chronic Kidney Disease in Côte d'Ivoire
Kouacou Kadio Morel *
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast and Medical Biology Laboratory, Haemodialysis Centre, Cocody Branch, Ivory Coast.
Kouamé-Dia Chantal
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Yayo Sagou Eric
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast and Medical Biology Laboratory, Haemodialysis Centre, Cocody Branch, Ivory Coast.
Yao-Yapo Carine
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast and Medical Biology Laboratory, Haemodialysis Centre, Cocody Branch, Ivory Coast.
Konan Jean Louis
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Koné-Dakouri Benédicte
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Koné Fatoumata
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Ahiboh Hugues
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Hauhouot-Attoungbré Marie-Laure
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
Monnet Dagui
Biochemistry Laboratory, Faculty of Pharmacy, Félix Houphouët Boigny University, Abidjan, Ivory Coast.
*Author to whom correspondence should be addressed.
Abstract
Background: Unlike creatinine, serum cystatin C concentrations are primarily determined by glomerular filtration and are not affected by tubular secretion. Several clinical studies suggest a close association between serum cystatin C concentrations and glomerular filtration rate. In addition, these concentrations may vary according to the ethnic origin of the population. However, cystatin C remains insufficiently studied in Black African populations, particularly in Côte d’Ivoire.
Aims: The study aims to characterise the serum cystatin C profile in a cohort of Ivorian adults with chronic kidney disease in Côte d’Ivoire.
Materials and Methods: This study included 100 patients (61 men and 39 women; aged 19–64 years) with chronic renal failure who were followed in the nephrology department of the Yopougon University Hospital Center in Abidjan. The estimated glomerular filtration rate (eGFR) was calculated using the Modification of Diet in Renal Disease (MDRD) equation without an ethnic correction factor. Cystatin C concentrations were measured by an immunoturbidimetric method using the Cobas Intégra 400 plus® analyser. The values were compared with those obtained from a population of presumed healthy Ivorian adults.
Results: The mean age of the patients was 45 years, and the male-to-female ratio was 1.56. The mean serum cystatin C concentration was 3.03 ± 1.28 mg/L. These concentrations were threefold higher than those of presumed healthy subjects and were significantly higher among patients with an eGFR below 30 mL/min/1.73 m². Serum cystatin C was inversely correlated with eGFR (rs = −0.709; p < 0.0001). Concentrations were also higher among patients aged 50 years or older (3.31 ± 1.12 mg/L). However, no significant differences in mean cystatin C concentrations were observed according to sex or body mass index.
Conclusion: These preliminary findings indicate that serum cystatin C concentrations are associated with lower eGFR in Ivorian patients with chronic kidney disease. Further studies involving larger clinical cohorts and different stages of disease progression are required to assess its clinical utility.
Keywords: Cystatin C, chronic kidney disease, estimated glomerular filtration rate, renal function, serum biomarker, renal impairment, MDRD equation, Ivorian adults