International Journal of Biochemistry Research & Review http://journalijbcrr.com/index.php/IJBCRR <p style="text-align: justify;"><strong>International Journal of Biochemistry Research &amp; Review (ISSN: 2231-086X)</strong> publishes original research papers, review articles and short communications on all areas of Biochemistry.&nbsp;This is a quality controlled,&nbsp;OPEN&nbsp;peer reviewed,&nbsp;open access INTERNATIONAL journal.</p> SCIENCEDOMAIN international en-US International Journal of Biochemistry Research & Review 2231-086X Correlation of Leptin and Vaspin Serum Concentration in Newly Diagnosed Type 2 Diabetes Mellitus http://journalijbcrr.com/index.php/IJBCRR/article/view/30160 <p><strong>Objectives: </strong>The aim of the study was to explore the correlation of circulating leptin and vaspin levels with lipid profile, fasting blood sugar, HbA1c and anthropometric variable as inflammatory markers between diabetic patients and non-diabetic subjects.</p> <p><strong>Material and Methods: </strong>This study was conducted with 120 newly diagnosed type 2 diabetes mellitus (T2DM) patients with age-matched 120 non-diabetic subjects as controls.</p> <p><strong>Results: </strong>We found that there is significant increase in the parameters like serum Leptin, Vaspin, FBS, PPBS, HbA1c and lipid profile (TC, TG &amp; VLDL). No significant differences were found between BMI, LDL &amp; HDL parameters of T2DM patients compared to non-diabetic subjects. The results have been shown a significant positive correlation between Vaspin and Leptin in T2DM patients, (r = .755) and (<em>P˂0.01</em>) as compared to controls. The body mass index was positively correlated with Vaspin in T2DM patients, (r = .50) and (<em>P </em><em>&lt;0.01</em>) and with leptin in T2DM patients, (r = .265) and (<em>P </em><em>&lt;0.01)</em>. A positive correlation had also observed between vaspin and LDL in T2DM patients, (r = .189) and (<em>p </em><em>&lt;0.05</em>). We also found that significant increased level of leptin and vaspin in females compared to males in our study group.</p> <p><strong>Conclusions:</strong> Serum leptin and vaspin level is positively associated with BMI and LDL and negatively correlated with fasting blood sugar, post-prandial glucose, HbA1c, VLDL and age.</p> K. Priya S. K. Bansal D. K. Sharma K. Y. Birendra ##submission.copyrightStatement## 2020-02-07 2020-02-07 1 9 10.9734/ijbcrr/2020/v29i130160 Effect of Leaf Extract of Senna alata on Biochemical Indices of Wistar Rats Infected with Trypanosoma brucei brucei http://journalijbcrr.com/index.php/IJBCRR/article/view/30161 <p>This study was aimed at determining the effect of leaves of <em>Senna alata </em>extract on biochemical indices of Wistar rats infected with <em>Trypanosoma brucei brucei</em>. Phytochemical screening revealed the absence of steroids in all extracts, absence of saponins in chloroform extracts and the presence of free anthraquinones only in chloroform extract. Post-infection treatment of animals stirred the emergence of parasitaemia by Day 3. Only animals receiving 200 mg/kg b.wt. of chloroform extract survived by day 16. A significant (P&lt;0.05) decrease in ALT for groups receiving methanol (400 mg/kg b.wt.), chloroform and aqueous extracts and significant (P&lt;0.05) increase in unconjugated bilirubin in the group receiving methanol extract (200 mg/kg b.wt.) compared to infected not treated rats. Significant (P&lt;0.05) decrease in potassium concentration in groups receiving methanol and chloroform, and a significant (P&lt;0.05) increase in sodium concentration in the group receiving 400 mg/kg b.wt. of aqueous extract compared to the infected not treated rats. These results thereby demonstrate the ameliorative potential of <em>Senna alata </em>leaves against <em>T. brucei brucei</em>.</p> M. A. Kugama T. Tese H. Sabo T. Andrew Y. A. Onaolapo O. G. Allen A. Agbo D. W. Danjuma A. M. Usman L. M. Umar P. J. Baji ##submission.copyrightStatement## 2020-02-07 2020-02-07 10 19 10.9734/ijbcrr/2020/v29i130161