Effect of Chelation Therapy and Blood Transfusion on Trace Elements in Thalassemia Patients

Main Article Content

Vijaysinh R. Parmar
Kuldip Singh
Asha Khubchandani

Abstract

Background: β-Thalassemia major is considered to be one of the most common inherited hemolytic anemia. Enhanced years of survival of thalassemia have led to unmasking related complications related to alterations in certain trace elements like magnesium, calcium, phosphorus, copper, zinc etc.

Objective: Present study was conducted to evaluate the effect of iron chelation therapy and blood transfusion on certain trace elements (Magnesium, Calcium, Phosphorus, Copper, Zinc) in β-thalassemic patients on chelation therapy more than one year.

Materials and Methods: In the present cross sectional study, 100 β-thalassemic patients receiving chelation therapy for atleast 1year were recruited from Civil Hospital Ahmedabad, Gujarat during February, 2017 to December, 2018 and equal  number (n=100) of healthy subjects were taken as a control group in the age range of 8 to 15 years of both sexes (male & female). The levels of serum magnesium, calcium, phosphorus, zinc, and copper in serum were analyzed and results were correlated with normal healthy subjects.

Results: A significant increase in serum copper (P≤ 0.01) and phosphorus (P≤ 0.001) were observed levels while a significant (P≤ 0.05) fall in magnesium, calcium and zinc levels recorded in β-thalassemic patients in comparison to healthy control subjects.

Conclusion: Aforementioned observations suggested that fluctuations in the trace elements levels in β- thalassemic children receiving blood transfusion and iron chelation therapy could leads to different complications like hemolyzed red cells, infections & hemochromatosis renal damage, hypoparathyroidism etc. if remains untreated. Hence routine assessment of these elements is recommended for better management.

Keywords:
β- Thalassemia, magnesium, calcium, phosphorus, copper, zinc.

Article Details

How to Cite
R. Parmar, V., Singh, K., & Khubchandani, A. (2019). Effect of Chelation Therapy and Blood Transfusion on Trace Elements in Thalassemia Patients. International Journal of Biochemistry Research & Review, 28(4), 1-5. https://doi.org/10.9734/ijbcrr/2019/v28i430152
Section
Original Research Article

References

Chiho W. Impact of essential trace elements on child growth and development. Jpn J Health & Human Ecology. 2017;83(6):184-190.

Taher AT, Otrock ZK, Uthman I, Cappellini MD: Thalassemia and hypercoagulability. Blood Rev. 2008;22:283-292.

Karatela S and Ward NI. Trace elements and human obesity: An overview. Manipal J. Nurs.& Health Sci. 2016;2(2):50-59.

Soliman TN. Banna M, Abdel FM, Zalabani EL, Ansari BM. Bone mineral density in prepubertal children with beta thalassemia: Correlation with growth and hormonal data. Metabolism. 1998;47:541-548.

Eithar EAK, Salama KM, Nagwa MET. An Updated Study of Some Trace Elements in Patients with Thalassemia Major. World Journal of Medical Sciences. 2013;9(2):97-101.

Tietz Textbook of clinical chemistry and molecular diagnostics, 4th Edition Page: 1126-1130.

Rahul AG, Kumbar KM, Suryakar AN. Oxidative stress and disturbance in antioxidant balance in beta thalassemia major. Indian J Clin Biochem. 2008;23: 337–340.

Rawa R, Salh DM, Dllzar DG. Effect of Desferrioxamine Injection on Some Metal Ions in β-Thalassemia Major Patients. Inter. J. Basic & Applied Sci. 2015;15:25-27.

Hatice G, Acipayam C, Serkan K, Sevcan I. Assessment of serum zinc status of children. J. of Pediat. Perinatol & Child Health. 2018;1:10-15.

Goyal M, Arora P, Lal H. Parathyroid and calcium status in patients with thalassemia. Indian J Clin Biochem. 2010; 25:385–387.

Asmaa N, Eman N, Hanaa NH, Khalid AF, Eman A, Elmawgoud A, Mohammed MS. Alteration of trace elements and T-cell subsets in patients with β-thalassemia major: Influence of high ferritin level. Egy. J. Haematol. 2018;43(2):35- 41.

Dandona P, Menon RK, Houlder S. Serum 1, 25 dihydroxyvitamin D and osteocalcin concentration in thalassemia major. Arch. Dis. Child. 1987;62:474–477.