Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity

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Swati Digambar Sawant
Mukund R. Mogarekar


Aims: The aim of the study was to evaluate the status and diagnostic utility of PON1. (Paraoxonase-1) Arylesterase and nitric oxide as indicator of antioxidant status in preeclampsia.

Study Design:  Analytical case control study.

Place and Duration of Study: Sample: Department of obstretics and gynecology Department, G. M. C. Ambajogai, between July 2010 and July 2012.

Methodology: We conducted a case-control study of 57 women with preeclampsia and 57 women with uncomplicated deliveries. We measured PON1 Arylesterase activity, Nitric oxide and lipid profile.

Results: Serum levels of LDLc (low density lipoprotein cholesterol) are higher in cases than in controls and are statistically significant (p=0.023). However serum HDLc (high density lipoprotein cholesterol) levels are decreased significantly (p = 0.017). Serum PON1 Arylesterase showed significant decrease in cases152.68 KU/L versus controls 180.89 KU/L, p value=0.002.  Serum nitric oxide also showed significant decrease in cases 22.77 ± 4.792 umol/L versus controls 25.127 umol/L, p=0.010. PON1 Arylesterase activity is found to be positively correlated with serum HDL cholesterol (r = 0.449, p value< 0.001). Multivariate logistic regression analysis was done.

Conclusion: Our observed results show decrease in the antioxidant PON1 Arylesterase activity point towards their role in the pathogenesis of Preeclampsia.

Arylesterase, paraoxonase, preeclampsia, nitric oxide.

Article Details

How to Cite
Sawant, S. D., & R. Mogarekar, M. (2019). Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity. International Journal of Biochemistry Research & Review, 27(4), 1-10.
Original Research Article


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