Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity

Main Article Content

Swati Digambar Sawant
Mukund R. Mogarekar

Abstract

Aims: The aim of the study was to evaluate the status and diagnostic utility of PON1. (Paraoxonase-1) Arylesterase and nitric oxide as indicator of antioxidant status in preeclampsia.

Study Design:  Analytical case control study.

Place and Duration of Study: Sample: Department of obstretics and gynecology Department, G. M. C. Ambajogai, between July 2010 and July 2012.

Methodology: We conducted a case-control study of 57 women with preeclampsia and 57 women with uncomplicated deliveries. We measured PON1 Arylesterase activity, Nitric oxide and lipid profile.

Results: Serum levels of LDLc (low density lipoprotein cholesterol) are higher in cases than in controls and are statistically significant (p=0.023). However serum HDLc (high density lipoprotein cholesterol) levels are decreased significantly (p = 0.017). Serum PON1 Arylesterase showed significant decrease in cases152.68 KU/L versus controls 180.89 KU/L, p value=0.002.  Serum nitric oxide also showed significant decrease in cases 22.77 ± 4.792 umol/L versus controls 25.127 umol/L, p=0.010. PON1 Arylesterase activity is found to be positively correlated with serum HDL cholesterol (r = 0.449, p value< 0.001). Multivariate logistic regression analysis was done.

Conclusion: Our observed results show decrease in the antioxidant PON1 Arylesterase activity point towards their role in the pathogenesis of Preeclampsia.

Keywords:
Arylesterase, paraoxonase, preeclampsia, nitric oxide.

Article Details

How to Cite
Sawant, S. D., & R. Mogarekar, M. (2019). Decreased Level of Nitric Oxide in Preeclamptic Pregnancy: A Relationship with PON1 Arylesterase Activity. International Journal of Biochemistry Research & Review, 27(4), 1-10. https://doi.org/10.9734/ijbcrr/2019/v27i430128
Section
Original Research Article

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